Brain Function and Treatment Response for Internet Addiction Across the LifeSpan

1.0 CE Credit

Presented by:
David R. Rosenberg, MD
Chair, Dept. of Psychiatry & Behavioral Neurosciences 
Wayne State University 

Internet addiction or compulsive use of the internet has become an increasingly prevalent public health concern. The relationship between the clinical phenomenology and modes of brain dysfunction remains unclear. We describe an integrated series of clinical, neurobehavioral, and functional magnetic resonance imaging (fMRI) studies in patients with internet addiction. Based on findings from these studies, there appear to be at least four subtypes of internet addiction, including impulse control subtype, obsessive-compulsive subtype, inhibited (depressed-anxious) subtype, and combined impulse control and obsessive-compulsive subtype. fMRI studies reveal significantly decreased regional brain activation in response to targeted attention and working memory tasks in patients with internet addiction compared to healthy controls. After effective treatment, there appears to be normalization in brain circuitry; however, relapse in symptoms was associated with the reappearance of brain abnormalities. The need for transdisciplinary team interventions including psychiatry, neuropsychology, and innovative brain imaging techniques will be emphasized.

After the webinar, participants will be able to:
1. Describe the critical role of neuropsychology in the elucidation of potential brain mechanisms involved in the pathogenesis of internet addiction across the lifespan.
2. Identify key neuroimaging paradigms that are delineating regional brain abnormalities in internet addiction and their potential significance for enhanced diagnosis and treatment.
3. Discuss novel neurobehavioral and cognitive probes used during functional MRI studies and their role in further elucidating the pathogenesis of internet addiction.

Target Audience: Primary care providers, mental health providers, and direct patient care providers in other disciplines

Instructional Level: Introduction

Dr. David Rosenberg is Chair of the Department of Psychiatry & Behavioral Neurosciences at Wayne State where he also serves as the Director of the Translational Neurosciences Institute and the Miriam Hamburger Endowed Chair of Child Psychiatry. His research has focused on imaging genetic studies of neuropsychiatric disorders and he has led several large NIH consortium grants as lead PI at the lead/coordinating site. He has published extensively and been the recipient of numerous honors and awards including receiving first prize in the neuropsychoparmacology competition at the International Congress of Neuropsychopharmacology, the A.E. Bennett Award from the Society of Biological Psychiatry and the Psychiatric Times Teacher of the Year. He also published the first textbook on pediatric Psychopharmacology now in its third edition. He is frequently sought out by the national media and his research has been featured several times on the NBC Today Show, ABC 20/20, Good Morning America, ABC World News Tonight, CNN, PBS and NPR.

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Characterizing Neurocognitive Heterogeneity in Bipolar Disorder: Clinical Correlates and Inflammation-based Biomarkers

1.25 CE Credits

Presented by:
Dr. Katherine E. Burdick
Associate Professor of Psychology in Psychiatry
Harvard Medical School

Many patients with bipolar disorder (BD) suffer from persistent cognitive impairments, even during periods of effective remission, which contribute directly to functional disability. At the group level, the severity of these deficits is ¾ to 1 full standard deviation below average; however, substantial cognitive heterogeneity exists. Convergent data suggest that a cumulative burden of disease (e.g., recurrent mood episodes and other comorbid features) triggers a pro-inflammatory cascade, which drives the brain changes associated with cognitive and functional decline.  

After the webinar, participants will be able to:
        1. Characterize the cognitive profile common to bipolar disorder and compare it with that seen in schizophrenia.
        2. Identify the clinical correlates and biomarkers of cognitive impairment in bipolar patients.
        3. Describe the cognitive trajectory in bipolar disorder including both neurodevelopmental and neurodegenerative processes.

Target Audience: Psychologists, Neuropsychologists, Researchers or Clinicians treating patients with psychiatric diseases or symptoms; graduate students, other psychology trainees.

Instructional Level:

Dr. Katherine E. Burdick
is an Associate Professor of Psychology in Psychiatry at Harvard Medical School. She is the Director of the Mood and Psychosis Research Program and the Associate Vice Chair for Research in Psychiatry at Brigham and Women’s Hospital in Boston, MA. She has expertise in clinical and neurocognitive assessment across a range of patients with serious mental illness, including schizophrenia and bipolar disorder. 

Dr. Burdick obtained her Ph.D. in Clinical Neuropsychology from the City University of New York-The Graduate Center and completed her clinical internship and her postdoctoral fellowship at Yale University School of Medicine. She is a licensed clinical psychologist in the state of NY.

Dr. Burdick has a strong track record of both federal and foundation funding, with a primary research focus on identifying persistent cognitive deficits in major psychiatric disorders, understanding their etiologies, and directly targeting them with treatment. She has collaborated on a wide range of projects including neuroimaging, genetics, and treatment trials in patients with bipolar disorder, schizophrenia, and major depression and has authored more than 130 peer-reviewed publications in this area.

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